The interrelationship between theory, knowledge, research and evidence-based practice (EBP) is an area where doctoral researchers and scholars have explored extensively. In general, research yields knowledge necessary for the formulation of theory that eventually informs evidence-based practice in any field. According to Fawcett and Garity (2009), the quality of evidence-based practice is directly reliant on high quality research. In other words, quality research yields quality knowledge, which informs highly feasible and plausible theoretical frameworks. Fawcett and Garity (2009) add that the ongoing emphasis on evidence in practice is, in itself, proof supporting the criticality of nursing theory, which guides critical and creative thinking in the decisions involved in EBP. They define evidence-based practice as the deliberate application of theories about health experiences of human beings as guidance to elements of the nursing process, including assessment, planning, intervention, and evaluation. Research comprises theories, conceptual models, and methods. The conceptual models are meant to guide research, which generates testable middle-range theories. It is through the use of vital frameworks in nursing practice decision-making that application of evidence-based and best practices can improve (Fawcett & Garity, 2009). The interrelationship means that all the components can only function properly when all of them are applied. None of them can be ignored if evidence-based practice is meant to inform top-quality nursing outcomes.